No detrimental effect of fibrin glue on the regeneration of intrabony defects
The aim of this study was to determine whether the application of fibrin glue had any detrimental effect on healing when used in conjunction with nonresorbable barrier membranes, and to assess its potential use as a biological carrier for GTR modulators. Two contralateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (Teflon membrane and fibrin glue) and the control (Teflon membrane alone). Outcomes were assessed at membrane removal as newly formed granulation tissue, and at the one-year follow-up in terms of the gingival margin, probing bone levels, and percentage of fill of the intrabony defects.
The results confirmed that GTR treatment of deep defects results in clinically and statistically significant improvements of the clinical parameters. No significant differences were evidenced between the test and the control treatments. Fibrin glue did not show detrimental effects on GTR, investigators concluded; thus it could be applied as a biological carrier for the delivery of GTR enhancers into the surgical wound. [S.L.]
Cortellini P., G.P. P. Prato, and M.S.Tonetti, J Clin Periodont, 22:697,1995