Gingival crevicular stromelysin collagenase and tissue inhibitor of metalloproteinases levels in healthy and diseased sites
This study measured GCF levels of fibroblast-type collagenase (FIB-CL), stromelysin (SL), and metalloproteinases (TIMP) from healthy, gingivitis, and periodontitis sites. Forty patients each provided three GCF samples from healthy, gingivitis, and periodontitis sites. GCF samples were collected by means of sterile paper strips. The mean amounts of SL and TIMP in diseased sites (gingivitis and periodontitis) were significantly higher than the mean amounts of these GCF components in healthy sites. GCF SL and TIMP differentiated healthy from diseased sites. Both SL and TIMP showed moderate correlation with clinical indices. FIB-CL was detectable in only 20.8% of all sites and did not correlate with disease status. [s.~.]
Haerian, A., E. Adonogianki, J. Mooney, J.P. Docherty, and D.F. Kinane, J Clin Periodont, 22:505, 1995