The purpose of the study was to determine the presence and quantity of IgG and albumin in specific gingival/periodontal tissues and serum from patients diagnosed having JP.
19 Patients 13 to 21 years old diagnosed having localized periodontitis according to the criteria of Baer were selected. 16 of those were black. During full thickness flap surgery with a scalloped internally beveled incision normal marginal tissue, diseased pocket gingiva and granulomatous tissue from the depth of the pocket was obtained from each operated site. The specimens were immediately washed and frozen to -70 Celsius. After thawing the tissue was homogenized, re-centrifuged and the supernatant re-frozen at -70 Celsius. 10 ml venous blood was obtained prior to surgery and after centrifugation the serum frozen to -20 Celsius. Immuno-electrophoresis was performed to determine the IgG and albumin concentrations.
The mean IgG/albumin ratio from serum did not differ from normal gingiva. However, serum and normal gingiva were significantly lower than diseased tissue and granulomatous tissue. When expected gingival concentrations based on the IgG/albumin rations were compared with IgG levels in the tissue samples, local production averaged 58% for diseased tissue and 80.1% for granulomatous tissue and 73.6% for the combined ( diseased and granulomatous ). In comparing the values with normal tissue samples local production was found to be 53% in diseased tissue and 78.26% in granulomatous tissue. The author concludes that surgical removal of the tissue with the highest disease activity might be necessary in the treatment of JP.
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