Addy M, Douglas WH,: A chlorhexidine-containing methacrilic gel as a periodontal dressing. J Periodontol, 46:465,1975.

Report the ability of a methacrylate gel to carry and release chlorhexidine acetate.

Materials and Methods

• Gel with Chlorxedine incorporated from 0.25% to 8%
• Oxford Staph. was inoculated to cultures for 24h at 37 C in the presence or not of CHX
• Measurement of zone of inhibition
• The 2% CHX was compared to Coe Pak against a range of organisms
• The 2% CHX was also placed in 10 patients. receiving GV. At seven days dressing was removed and then inoculated with Oxford Staph.

Results

• Dressing containing 0.25-0.5% CHX had antibacterial activity up to 6-17 days.
• The ones wit more than 0.5% inhibited bacterial growth for more than 24 days.
• The CHX free gel and Coe-Pak had limited antibacterial activity.
• The dressing containing CHX removed 1 week after surgeries had antibacterial activity

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