Periodontology Literature Review

ANTIBIOTICS: SYSTEMIC DELIVERY

Isabelle Demolon et al: Effects of Antibiotic Treatment on Clinical Conditions with Guided Tissue Regeneration: One Year Results. J Perio, 65:713-717, 1994.

Purpose:

To assess if 10 day course of Amoxicillin/Clavulanate potassium (ACP) enhanced the outcome of the procedure after 1 year.

Methods and materials:

A total of 15 patients were included in this study. The patients were allocated into the following treatment groups; 8 patients with 12 surgical sites no ACP (group 1), and 7 patients with 12 sites (group 2) and ACP for 10 days. The sites were vital mandibular molars with class II furcations. Full thickness flaps were reflected. The area was debrided, measured, and ePTFE membrane was placed. Microbial samples were taken, inflammation was recorded weekly until membrane was removed (4 weeks). The patients were examined at 3-5 months intervals. Oral hygiene instructions (OHI) and prophylaxis were given; no subgingival debridement was performed. All 15 patients were asked to participate in re-entry study (2 refused). A total of 13 patients had a re-entry surgery; 8 patients in group 1 (12 sites), 5 patients in group 2 (10 sites). Prior to re-entry; probing depth (PD), recession, and horizontal component of furcations were recorded.

Results:

Soft tissue; no difference in PD between 2 groups; group 1 mean decrease in PD 2.0+/- 1.2 mm, and group 2 mean decrease, 1.8 +/- 1.1 mm. The recordings for recession were as follows; group 1, 1.2 mm +/- 1.0 mm, and group 2, 0.8 mm +/- 0.7 mm. Hard tissue measurements showed Not statistically significant differences. Group 1 and 2 demonstrated similar mean percentage of fill.

Conclusion:

The adjunct use of the antibiotic provided limited benefits. Use of antibiotic the first 10 days may have controlled initial inflammation but 13 months later it had no effect on bone regeneration or soft tissue attachment of clinical significance.

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