Periodontology Literature Review

ANTIBIOTICS: SYSTEMIC DELIVERY

Rozanis, J. et al: Spiramycin as a Selective Dental Plaque Control Agent. J Perio Res, 14:55, 1979.

Purpose:

To determine whether Spiramycin can prevent plaque build up in the absence of mechanical debridement. Also to evaluate the drug effect on "potential pathogens" such as S. sanguis and S. mutans, and to ascertain if the short term administration of Spiramycin results in adverse ecological imbalance of the bacterial components of dental plaque.

Materials and methods:

A total of 63 subjects with "health" to severe disease were included in this double blind study. Intra-oral photographs were taken. Plaque and gingival index were recorded, and plaque was collected for analysis. The following tests were used; Turbidity, biochemical test, bacteriological analysis. Treatment in the experimental group consisted of 20 capsules of Spiramycin (500 mg), 1 cap 4 times per day for 5 days.

Results:

Spiramycin decreased weight of plaque at week 1 and 3. Spiramycin decreased turbidity reading at 1 and 3 week. Spiramycin decreased nitrogen content at 3 weeks. There was a decrease in S. sanguis and S. mutans at weeks 1 and 3. There was no effect on gram negative species.

Conclusion:

Spiramycin result in significant decrease in plaque measured by weight, turbidity, and nitrogen content for at least 3 weeks. There was a decrease in S. mutants and S. sanguis at 1 and 3 weeks. No influence in the Gram negative species..

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