Periodontology Literature Review

ANTIMICROBIALS: FIBER DELIVERY

Morrison, RL., Cobb, CM., Kazakos, GM., and Killoy, WJ: Root surface characteristics associated with subgingival placement of monolithic tetracycline-impregnated fibers. J Perio, 63(2):137-143, 1992.

Previous studies have shown that the use of tetracycline fiber-treated teeth showed a greater reduction in pocket depth, less bleeding upon probing, and a gain in attachment level than scaling and root planing or non-treated control teeth (Heijl, L Ś91 and Goodson, J. Ś85).

Purpose:

This study wanted to test the penetration on the dentition of this fiber and examine the viability and types of bacteria after the use of scaling and root planing with and without the use of a treatment fiber.

Result:

A 10-day exposure in vivo with a 25% tetracycline hydrochloride fiber matrix was utilized on 8 patients and on 32 teeth which were to be extracted due to severe periodontal disease.

A fluorescent-light microscopy and an energy dispersive spectroscopy demonstrated penetration into the root surface of about 10 µm. The treatment groups which had fiber alone and scaling and root planing with fiber showed significantly greater reduction in numbers and viability (scanning electron microscopy showed loss of membrane integrity) in bacteria. The control groups consisted of scaling and root planing and no scaling and root planing or fiber. The one control that would have been interesting to see would be a fiber group without tetracycline to test the negative effects of a fiber in the sulcus for a 10 day period.

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