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ANTIMICROBIALS: RINSES
Firatli, E. et al: Antioxidative Activities of Some Chemotherapeutics.
A Possible Mechanism in Reducing Gingival Inflammation.
J Clin Perio, 21:680-683, 1994.
Purpose:
To investigate antioxidative activities of chemotherapeutic agents such as chlorhexidine (CHX), Listerine, sangiunarine and acetylpyridium chloride and oral antibiotics such a tetracycline HCl and doxycycline.
BACKGROUND: increase in blood flow rate in inflamed gingiva results in increase O2 supply to tissue. Although O2 has a healing effect it is a mediator of peroxydation in biological membranes. Excessive peroxydation of polyunsaturated fatty acids in biological membranes is thought to be related to inflammation.
Results:
Doxycycline has a highest antioxidant activity in lower volumes ( 0.1 ml). Sanguinarine, Listerine, tetracycline HCl have similar effect in higher volume ( 0.3, 0.4 ml).
Conclusion:
These preparations have an antioxidative activity against spontaneous oxidation in addition to their antiseptic and antimicrobial effect.
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