Periodontology Literature Review

ANTIMICROBIALS: RINSES

Lyndsey Hunter et al: A Study of a Pre-Brushing Mouthrinse as an Adjunct to Oral Hygiene. J Perio, 65:762-765, 1994.

Purpose:

The purpose of this 6 week clinical trial was to extend the previous study and evaluate the combination of CPC and essential oils for effects against supragingival plaque, when used prior to conventional toothbrushing with a dentrifice.

Materials and methods:

Comparisons were made with a negative control and a marketed pre-brushing rinse containing triclosan and a copolymer. The triclosan/copolymer marketed rinse was included because previously reported short term studies had shown it to have significant plaque inhibitory action when used prior to normal brushing. This study was designed so that at least 50 subjects per group would complete this 4 group, double blind, parallel group clinical trial. Subjects were randomly allocated to use 1 of 4 formulation as pre-brushing rinses for a period of 6 weeks. The rinse formulations were as follows: 1) experimental rinse 1 containing CPC and essential oils, 2) experimental rinse 2 was a variation of rinse 1, 3) a rinse containing 0.03% triclosan/copolymer and 4) negative control mouthrinse containing 5% hydroalcohol. Subjects were rendered plaque free at baseline and then rinsed twice daily before toothbrushing. Plaque was scored at 6 days and 6 weeks.

Results:

Plaque scores were reduced at 6 days compared to baseline, but there was no significant difference between any of the groups. At 6 weeks, plaque scores were significantly lower in both CPC/essential oil groups compared to control. Although CPC/essential oil groups showed plaque score which were lower than the triclosan group, in only one of the groups was the difference significant. The triclosan product was not significantly different from control.

Conclusion:

The results indicate that a CPC/essential oil rinse could be useful as an adjunct to oral hygiene when used prior to normal brushing.

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