Periodontology Literature Review

ANTIMICROBIALS: RINSES

David Abbott et al: The Relative Efficacy of 0.1% and 0.2% Delmopinol Mouth rinses in Inhibiting the Development of Supragingival Plaque and Gingivitis in Man. J Perio, 65:437-441, 1994.

Purpose:

To compare antiplaque, antigingivitis and safety of 0.1% and 0.2% delmopinol mouth rinses (DMP). To determine is a dose response antiplaque, antigingivitis is found in this formulation.

Materials and methods:

A total of 150 subjects (133 finished) were include in this study. The patients were divided into 3 groups; 0.1% DMP, 0.2% DMP, and control. Baseline examination was performed followed by scaling. The subjects refrained from oral hygiene methods for 2 weeks, except for mouthrinse. Rinses were used 2 X a day for 2 weeks.

Results:

There was an imbalance in the sample; 0.2% more whites, 0.1% more smokers.
Plaque indices showed high levels maxillary facial, low level for maxillary palatal. Moderate levels for mandibular teeth. There was a reduction in plaque in all 3 groups (larger reduction on linguals). In the control, there was a small increase in the plaque level over 2 weeks, more on facial, less on lingual sites. The gingival responses were not statistically significant. 0.2% DMP appeared to be the optimum level. There was a lineal relation between plaque and concentration of DMP. DMP was more effective on linguals than on facials.

Conclusion:

DMP has antiplaque properties and no significant treatment effect on gingival inflammation on a short term clinical trial (2 weeks).

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