Periodontology Literature Review

CHLORHEXIDINE

Moran, J., Addy, M., Kohut, B., Hovliaras, C., and Newcombe, R: Efficacy of Mouth rinses in Inhibiting the Development of Supragingival Plaque over a 4 day Period of no Oral Hygiene. J. Perio 65:904-907, 1994.

Purpose:

To screen an experimental mouthrinse containing CPC for its effect on plaque accumulation.

Materials and methods:

15 subjects were included in this study. Patients did not brush to allowed 4 days for plaque regrowth. The patients were randomly allocated into 5 groups: Experimental CPC, Triclosan, negative control, second negative control, Chlorhexidine (CHX). Day 1 consisted of exam, scaling and polishing. Oral hygiene was suspended . The patients were advised to rinse twice a day (under supervision). On day 5 examination was performed, plaque index was recorded, and prophylaxis was completed. On each weekend toothbrushing was reestablished. Then patients were advised to start a new rinse the first day of the week. Each subject used a total of 5 rinses.

Results:

The most effective was rinse was CHX; then CPC, Triclosan, and the least effective were the two negative controls. Each rinse differ significantly to each other, except the negative controls. The mean position of CPC relative to Triclosan and CHX appears to be 30-50%.

Conclusion:

CPC produced plaque inhibition. No side effects were reported. CPC may be used as an adjunct to mechanical oral Hygiene.

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