Literature Review | Chemotherapeutics

Overview
TEXT.GIF (137bytes)Chemotherapeutics Introduction
Loesche, W.J. Chemotherapy of dental plaque infections. Oral Science Review. 9:65, 1976.
Gjermo, P., K. Baastad, and G. Rolla. The plaque-inhibiting capacity of 11 antibacterial compounds. J. Periodont. Res., 5:102; 1970.

CHLORHEXIDINE
Tonelli, Hume and Kenney: Chlorhexidine: A Review of the Literature. J of Western Society of Perio. Vol 31:No 1:1983.
Loe, H. and Schiott, C.K. : The Effect of Mouthrinses and Topical Application of Chlorhexidine on the Development of Dental Plaque and Gingivitis in Man. J. Perio Res. 5:79, 1970.
Gjermo, P. Chlorhexidine in dental practice. J. Clin. Periodontol. 1:143, 1974.
Addy, M. and L. Hunter. The Effects of a 0.2% chlorhexidine gluconate mouthrinse on plaque, tooth staining, and candida in aphtous ulcer patients. A double-blind placebo-controlled cross-over study. J. . Periodontol., 14:267;1987.
Taggart, JA, Palmer, RM, and Wilson, RF: A clinical and microbiological comparison of the effects of water and 0.02% chlorhexidine as coolants during ultrasonic scaling and Root Planing . J. Clin. Periodontol. 17(1):32-7, 1990.
Moran, J., Addy, M., Kohut, B., Hovliaras, C., and Newcombe, R: Efficacy of Mouth rinses in Inhibiting the Development of Supragingival Plaque over a 4 day Period of no Oral Hygiene. J. Perio 65:904-907, 1994.
Albandar, J., Gjermo, P., and Preus, H.: Chlorhexidine Use After Two Decades of Over-the-counter Availability. J. Perio 65:109-112, 1994.

ANTIMICROBIALS: RINSES
Mankodi, S., Ross, NM, and Mostler, K.: Clinical Efficacy of Listerine in Inhibiting and Reducing Plaque and Experimental Gingivitis. J Clin Perio 14:285, 1987.
Wolff, LF., Philstrom, BL., Bakdash, MB., et al: Salt and Peroxide compared with conventional oral hygiene II. Microbial Results. J. Perio, 58:301, 1987.
Wolff, LF., Philstrom, BL., Bakdash, MB., Schaffer, EM., Aeppli, DM., and CL Bandt : Four Year Investigation of Salt and Peroxide Regimen compared with Conventional Oral Hygiene. JADA 118:67, 1989.
Mazza, J. et al: Clinical and Antimicrobial Effect of Stannous Fluoride on Periodontitis. J. Clin Perio 8(3):203, 1981.
Tinanoff, N., Brady, J., Gross, A.: The Effect of NaF and SnF2 Mouth rinses on Bacterial Colonization of Tooth Enamel: TEM and SEM studies. Caries Res. 10:415, 1976.
David Abbott et al: The Relative Efficacy of 0.1% and 0.2% Delmopinol Mouth rinses in Inhibiting the Development of Supragingival Plaque and Gingivitis in Man. J Perio, 65:437-441, 1994.
Denis M. OíMullane et al: A 12-Month Study of the Efficacy of a Pre-Brushing Rinse in Plaque Removal. J Perio, 65:611-615, 1994.
Lyndsey Hunter et al: A Study of a Pre-Brushing Mouthrinse as an Adjunct to Oral Hygiene. J Perio, 65:762-765, 1994.
Firatli, E. et al: Antioxidative Activities of Some Chemotherapeutics. A Possible Mechanism in Reducing Gingival Inflammation. J Clin Perio, 21:680-683, 1994.
Vouros, J. et al: Effects of a New Pre-Brushing Rinse on Dental Plaque Removal. J Clin Perio, 21:701-704, 1994.

ANTIMICROBIALS: TOPICAL
Loesche, W., E. Green, EB. Kenney, and D. Nafe. Effect of topical Kanamycin sulfate on plaque accumulation. JADA, 83:1069, 1971.
Kaslick,, R., Tuckman, M., and Chasens, A.: Effect of topical vancomycin on plaque and chronic gingival inflammation. J Perio, 44:366, 1973.
Klinge, B., Attstrom, R., Karring, T., Kisch, J., Lewin, B., Stoltze, K.,: 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. J Clin Perio, 19 (9 p2):708-714, 1992.
Ainamo, J., Lie, T., Ellingsen, BH., Hansen, BF., Johansson, LA, Karring, T., Kisch, J., Paunio, K., Stoltze, K.: Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. J Clin Perio, 19(9 p2):723-729, 1992.
Pedrazzoli, V., Kilian, M., Karring, T.: Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis. J Clin Perio, 19(9 p2):715-722, 1992.
Lone Sander et al: Effect of Local Metronidazole Application on Periodontal Healing Following Guided Tissue Regeneration: Clinical Findings. J Perio, 65:914-920, 1994.
Ellen V. G. Frandsen et al: Effect of Local Metronidazole Application on Periodontal Healing Following Guided Tissue Regeneration: Microbial Findings. J Perio, 65:921-928, 1994.
Arch Jones et al : Clinical and Microbiological Effects of Controlled-Release Locally Delivered Minocycline in Periodontics. J Perio, 65:0158-1066, 1994.
Atsushi Saito et al: Locally Delivered Minocycline and Guided Tissue Regeneration to Treat Post-Juvenile Periodontitis. A Case Report. J Perio, 65:835-839, 1994.

ANTIMICROBIALS: FIBER DELIVERY
Ciancio, SG., Cobb, CM., and Leung M.: Tissue concentration and localization of tetracycline following site-specific tetracycline fiber therapy. J Perio, 63(10):849-853, 1992.
Rapley, JW., Cobb, CM., Killoy, WJ., and Williams DR.: Serum levels of tetracycline during treatment with tetracycline containing fibers. J Perio 63(10):817-820, 1992.
Morrison, RL., Cobb, CM., Kazakos, GM., and Killoy, WJ: Root surface characteristics associated with subgingival placement of monolithic tetracycline-impregnated fibers. J Perio, 63(2):137-143, 1992.

ANTIBIOTICS: SYSTEMIC DELIVERY
Loesche, W. et al: Treatment of Perio Infection due to Anaerobic Bacteria with Short-Term Treatment with Metronidazole. J Clin Perio, 8:29, 1981.
Rozanis, J. et al: Spiramycin as a Selective Dental Plaque Control Agent. J Perio Res, 14:55, 1979.
Lindhe, J., Liljenberg, B., Aldielson, B., and Borjesson, I.: The effect of metronidazole therapy on human periodontal disease. J Perio Res 17:534, 1982.
Isabelle Demolon et al: Effects of Antibiotic Treatment on Clinical Conditions with Guided Tissue Regeneration: One Year Results. J Perio, 65:713-717, 1994.
Korman, K.S. et al: The Influence of Supragingival Plaque Control on Clinical and Microbial outcomes Following the Use of Antibiotics for the Treatment of Periodontitis. J Perio, 65:848-854, 1994.

DELIVERY BY IRRIGATION
Wennstrom, JL., G. Dahlen, K. Grondahl, and L. Heijl: Periodic subgingival antimicrobial irrigation of periodontal pockets. II. Microbiological and radiographical observations. J Clin Perio, 14:573, 1987.
Silverstein, Bissad, Manouchehr-Pour and Greenwell: Clinical and Microbioogical Effects of Local Tetracycline Irrigation On Periodontics. J Perio, 59:301, 1988.
Linden, GJ., and Newman, HJ: The effects of subgingival irrigation with low dosage metronidazole on periodontal inflammation. J Clin Perio, 18(3):177-181, 1991.
James B. Fine et al: Short-Term Microbiological and Clinical effects of Subgingival Irrigation with an Antimicrobial Mouth rinse. J Perio, 65:30-36, 1994.

EFFECTS ON ORAL MICROBIOTA
Wolff, LF. et al: Phase Contrast Microscopic Evaluation of Subgingival Plaque in Combination with either Conventional or Antimicrobial Home Treatment with Periodontal Disease. J Perio Res 17: 537, 1982.
Keyes, P. et al: The use of phase-contrast microscopy and chemotherapy on the diagnosis and treatment of periodontal lesions. An initial report I & II. Quint Int 1:51-56 & 2:69-76, 1978.

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