NaproxenCalifornia Continuing Education Credits: 2 units
PIC HOMEPAGE| Main Page | Ibuprofen | Acetaminophen | Diflunisal | Naproxen |
| Generic Name | Naproxen |
| Commercial Products | Naprosyn, Alleve, Anaprox |
| Structure | 5-6 methoxy-d-methyl 2-naphthaleneacetic acid, methoxy |
| Mode of Action | Non-steroidal anti-inflammatory agent which reduces prostaglandin activity. Has anti-inflammatory analgesic and some antipyretic activity. |
| Periodontal Indications | Control of postsurgical pain. Peak blood levels obtained in two to four hours, stays active as an analgesic for six to eight hours. |
| Dosage | Adults 500 mg naproxen followed by 250 mg every 6 to 8 hours. Do not exceed 1250 mg per day. Not recommended for pregnant or nursing women. |
| Side Effects | Gastrointestinal problems like constipation, heartburn pain, nausea, dyspepsia and diarrhea. Severe problems like gastric ulceration and bleeding are present in 1 to 4 percent of patients using naproxen for prolonged periods up to one year. Short term use does not cause changes in blood coagulation. Changes in vision, hearing disorders and vertigo have also bee reported with Naproxen. |
| Contraindication | History of allergic reactions to naproxen other non-steroidal anti-inflammatory drug and aspirin. |
| Precautions | Naproxen inhibits platelet aggregation but this effect usually causes small changes in bleeding time in normal patients. This is less than that seen with aspirin. Patients on anticoagulant therapy or with intrinsic bleeding disorders can be at risk for hemostatic problems with the concurrent use of ibuprofen. Patients with decreased renal or liver function, heart failure or under diuretic therapy can be at risk for liver dysfunction, renal failure, and fluid retention while taking Naproxen. Patients using beta blockers or ACE inhibitors can have complications if NSAIDS are used that can result in increased blood pressure. |
| Drug Interactions | Anticoagulants -see precautions |
| How Prescribed | Available in USA without prescription. Usual prescription is 500 mg followed by 250 mg every 6 to 8 hours as needed for control of post surgical pain for one to five day. |
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