| This is routine hematoxylin and eosin stain of a biopsy of an intact bulla from a patient with MMP. The oral stratified squamous epithelium has been entirely separated from the connective tissue at the level of the basement membrane. The histologic appearance is therefore markedly different from that seen in pemphigus, but identical to other bullous lesions including some viral blistering diseases and bullous pemphigoid. Note the fibrinous exudate and cell debris in the bulla's cavity. | |
| This photo shows a higher magnification of the previous slide. Note that the splitting has taken place at the level of the basement membrane, the epithelium being completely lifted from the connective tissue. At the angle of the bulla there is accumulation of a fibrinous exudate and plasma, which is a consequence of cell destruction. Note the inflammatory cellular infiltrate (mostly limphocytes) and capillaries in the connective tissue. |
|