Educational and Professional Background
B. S. 1984 Genetics, Fudan University, Shanghai, P.R.C.
Ph. D. 1991 Genetics, University of Wisconsin-Madison
1986-1991 Ph.D graduate student, Department of Genetics, University of Wisconsin-Madison. Conducted research projects at UW-Madison, Harvard University and Stanford University
1992-1995 Postdoctoral researcher and Assistant research microbiologist, Department of Molecular and Cell Biology, University of California-Berkeley
1996-2000 Assistant professor, School of Dentistry and Molecular Biology Institute, UCLA
2000-2002 Associate professor, School of Dentistry and Molecular Biology Institute, UCLA
Professor, School of Dentistry and Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, UCLA
Research/Creative Activities
Understanding the molecular mechanisms of bacterial signal transduction and biofilm formation using Myxococcus xanthus as the model bacteria, supported by a RO1 from NIGMS (P.I. Wenyuan Shi)
Understanding the molecular components involved in singlaing events during the biofilm formation of Streptococcus mutans, supported by grants from Delta Dental (P.I. Wenyuan Shi) and NIDCR (RO1, P.I. Fengxia Qi)
Analysis of chemotaxis and pathogenesis of oral spirochete Treponema denticola, supported by a grant from Delta Dental (P.I. Wenyuan Shi)
Development of monoclonal antibody based chairside instant test for detection of salivary S. mutans, supported by GC international (P.I. Wenyuan Shi)
Development of monoclonal antibody based chairside test for detecting the whole profile of cariogenic bacteria, supported by Ivoclar Vivadent (P.I. Wenyuan Shi)
Developing MEMS/NEMS based nanotechnology to detect bio-markers for cancers and oral pathogens in saliva, supported by NIDCR (P.I. David Wong, on oral cancer, Wenyuan Shi, project leader on oral pathogens)
Development of 3-D real time non-invasive imaging of dental plaque using monoclonal antibodies and confocal microscopy, supported by Colgate and Delta Dental (P.I. Wenyuan Shi)
Developing e-tooth, a microsensor which provides real time information of acidification and demineralization within dental plaque, supported by C3 Scientific Corp and BioSTAR (P.I. Wenyuan Shi)
Developing fusion protein and peptide based targeted anti-microbial pharmaceuticals for the treatement of dental caries and other microbial infections, supported by C3 Scientific Corp and BioSTAR (P.I. Wenyuan Shi)
Development of Chinese Medicinal Herbs based anti-cavity treatments, supported by C3 Scientific Corp and BioSTAR (P.I. Wenyuan Shi)
Courses taught
OB725, Molecular and Cellular Biology
Professional memberships and activities:
1987-present American Society of Microbiology
1995-present American Association for the Advancement of Science
1996-present American Association for Dental Research
- Member of UCLA Molecular Biology Institute
- Member of UCLA Dental Research Institute
- Member of UCLA Jonsson Cancer Center
- Editorial board, International Journal of Oral Biology
- Editorial board, Chemotaxis and Migration
- NIH MBC-1 regular review member
- NIH BM-1 Ad Hoc reviewer
NSF grant reviewer
Recent Publications
Shi, W., and H. Sun. 2002. Type IV pili dependent motility and its possible role in bacterial pathogenesis. Infection and Immunity. Vol. 70, p1-4.
Lancero, H., J. E. Brofft, J. Downard, B. W. Birren, C. Nusbaum, J. Naylor, W. Shi, and L. J. Shimkets. 2002. Mapping of Myxococcus xanthus social motility dsp mutations to the dif genes. J. Bacteriol. Vol. 184, p1462-1465.
Lux, R., J-H Sim, J. P. Tsai, and W. Shi. 2002. Construction and characterization of a cheA mutant of Treponema denticola. J. Bacteriol. Vol. 184, p3130-3134.
Gu, F., R. Lux, M. H. Anderson, M. A. del Aguila, L. Wolinsky, W.R. Hume and W. Shi. 2002. Analyses of Streptococcus mutans in saliva with species-specific monoclonal antibodies. Hybridoma and Hybridomics, Vol. 21, p225-232.
Bellenger, K., X. Ma, W. Shi, and Z. Yang. 2002. A cheW homologue is required for Myxococcus xanthus fruiting body development, social gliding motility, and fibril biogenesis. J. Bacteriol. Vol. 184. p5654-5660.
Gu, F., X. Ma, R. Lux, and W. Shi. 2002. Production and characterization of species-specific monoclonal antibodies against Actinomyces naeslundii and Lactobacillus casei. Hybridoma and Hybridomics, Vol. 21, p469-478.
Merritt, J., F. Qi, S. Goodman, M. H. Anderson, and W. Shi. 2003. Mutation of luxS affects biofilm formation in Streptococcus mutans. Infection and Immunity, Vol. 71, p1972-1979.
Li, Y., H. Sun, X. Ma, A. Lu, R. Lux, D. Zusman, and W. Shi. 2003. Extracellular polysacchrides mediate pilus retraction during social motility of Myxococcus xanthus. Proc. Natl. Acad. Sci. USA Vol. 100, p5443-5448.
Qi, F., J. Merritt, P. W. Caufield, and W. Shi. 2002. The ciaRH Two-component System in Streptococcus mutans Regulates Mutacin Production and Affects Competence Development. J. Bacteriol. (in press).
Wang, Y., W. Shi, W. Chen, C. Chen. 2002. Type IV pilus homologs pilABCD are required for the natural transformation in Actinobacillus actinomycetemcomitans. Microbiology (in press).
Gu, F., M. Anderson, W. Shi. 2002. Analysis of cariogenic bacteria within dental plaque using monoclonal antibodies based techniques. J. Bacteriol. (submitted).
Ma, X., H. Lee, A. Jewett, G. Chen, Z. Yang, N.-H. Park, B. Goodman and W. Shi. 2002. Programmed cell death in Myxococcus xanthus involves cytochrome C mediated chromosomal DNA degradation. Proc. Natl. Acad. Sci. USA (submitted).
Lancero, H., W. Shi, Z. Yang. 2002. Analysis of interactions between Dif proteins using yeast two hybrid system. J. Bacteriol. (submitted).
Ma, X., M. Kempf, A. Jewett, and W. Shi. 2002. Isolation and characterization of Fusobacterium nucleatum genes related to apoptotic death of human lymphocytes. Infection and Immunity (submitted).
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