Educational and Professional Background
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University of Athens, Greece
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DDS
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1989
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Dentistry
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University of Connecticut Health Center, CT
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Certificate
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1996
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Oral Radiology
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University of Connecticut Health Center, CT
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PhD
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1996
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Biomedical Sciences
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After completion of his dental degree at the University of Athens, Dr. Tetradis joined the combined Oral and Maxillofacial Radiology Certificate/Biomedical Science PhD at the University of Connecticut Health Center. After completion of his studies, he became a postdoctoral fellow at the NEB Bone & Joint Institute, BID Medical Center /Harvard Institutes of Medicine. In 1998, he joined the faculty at the UCLA School of Dentistry.
Research/Creative Activities
Dr. Tetradis' research concentrates on the molecular mechanisms of mineralized tissue biology. He believes that understanding the mechanisms that regulate bone and cementum homeostasis will help the design of anabolic treatments. Such treatments would be very beneficial in everyday dental practice, such as in periodontal regeneration, implant osseointegration, and fracture healing.
Patient Care Activities
Dr. Tetradis’ clinical interests focus on diagnostic Oral and Maxillofacial Radiology. He finds the combination of patient care, technology, physics, biology and computer analysis to be very challenging and appealing.
Courses taught
Radiographic Interpretation of Jaw Bone Pathology - Oral Radiology DS422b
Radiographic Differential Diagnosis - Oral Radiology DS423b
Advanced Topics in Oral Radiology - DS 300.07A (co-chair)
Professional memberships and activities:
Jonsson Comprehensive Cancer Center, UCLA
Dental Research Institute, UCLA
American Society of Bone and Mineral Research
Endocrine Society
American Academy of Oral & Maxillofacial Radiology
International Association of Dental Research
American Association of Dental Research
Recent Publications
Ozkurt IC and Tetradis S. Parathyroid hormone-induced E4BP4/NFIL3 downregulates transcription in osteoblasts. J Biol Chem, in press
Tetradis S and Kantor ML. Anomalies of the odontoid process discovered as incidental findings on cephalometric radiographs. Am J Orthod Dentofac Orthop in press
Pirih FQ, Nervina JM, Pham L, Aghaloo T, Tetradis S. Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts. Biochem Biophy Res Commun 2003; 306:144-50.
Nervina JM, Tetradis S, Huang Y-F, Harrison D, Molina C, Kream BE. Expression of inducible cAMP early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts. Bone, 2003; 32:483-490
Kaur M, Zhang Y, Tetradis S, Price B, and Makrigiorgos GM. Ligation of a primer at the mutation: a method to detect low level mutations in DNA. Mutagenesis, 2002;17:365-74
Zhang Y, Kaur M, Tetradis S, Price B and Makrigiorgos GM. An amplification and ligation-based method to scan for unknown mutations in DNA. Hum Mutat 2002; 20:139-47
Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, and Demer LL. 8-isoprostaglandin E2 enhances RANKL-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem 2002; 277: 14221-14226
Tsingotjidou A, Nervina JM, Pham L, Bezouglaia O and Tetradis S. Parathyroid hormone induces RGS-2 rxpression by a cyclic adenosine 3’-5’-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone 2002; 30: 677-684
Zhang Y, Price B, Tetradis S, Maulik G and Makrigiorgos GM. Reproducible and inexpensive probe preparation for oligonucleotide microarrays. Nucleic Acids Res 2001; 29:E66-6
Tetradis S, Bezouglaia O, Tsingotjidou A and Vila A. Regulation of the Nuclear Orphan Receptor Nur77 in Bone by Parathyroid Hormone. Biochem Biophys Res Commun 2001; 281:913-916
Tetradis S, Bezouglaia O, Tsingotjidou A. Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells. Endocrinology 2001; 146: 663-670
Chakrabarti S, Price B, Tetradis S, Fox EA, Zhang Y, Maulik G, and Makrigiorgos GM. Highly selective isolation of unknown mutations in diverse DNA fragments: Towards new multiplex screening in cancer. Cancer Res 2000; 60: 3732-3737
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