Educational and Professional Background
Bachelor of Science Agricultural Biology, Korea University. 1990
Master of Science Oral Biology (Molecular Oral Carcinogenesis)
School of Dentistry
University of California, Los Angeles. 1992
Doctor of Philosophy Oral Biology (Molecular Oral Carcinogenesis)
School of Dentistry
University of California, Los Angeles. 1995
Dr. Ki-Hyuk Shin received his Ph.D. in Oral Biology with emphasis on Molecular Oral Carcinogenesis from University of California, Los Angles School of Dentistry in 1995. Soon after, he was a Senior research scientist at Cancer Research Institute at School of Medicine at Seoul National University. He then was offered a faculty position as an assistant professor at Research Division of Human Life Science Seoul National University in the Department of Oral Biochemistry in College of Dentistry in 2001. During that time, he was involved as a principal investigator in cancer research in investigating Korean associated cSNP in hereditary tumor related genes and their relevance to disease.
In 2001, Dr. Shin joined the faculty of the UCLA School of Dentistry as an assistant professor. He is one of the few pure cancer biologists at the School of Dentistry and is currently investigating the role of DNA repair and genetic instability in oral carcinogenesis. Dr. Shin has more than 50 combined original scientific publications and proceedings. His major research activities have been in areas of (1) the role of DNA damage and repair in oral carcinogenesis, (2) role of telomerase activity in oral carcinogenesis, and (3) Replicative senescence of normal human oral cells.
Dr. Shin was also invited to numerous lectures, with the most current one given at UCLA Dental Research Institute with the title of Microsatellite instability and DNA mismatch repair genes in human cancer. Currently, he is teaching a course as a lecturer in Advanced Oral Biology – Pathobiology.
Research/Creative Activities
(1) Role of DNA damage and repair in oral carcinogenesis
(2) Role of telomerase activity in oral carcinogenesis
(3) Replicative senescence of normal human oral cells. .
Courses Taught
Advanced Oral Biology – Pathobiology
Professional memberships and activities:
American Association of Cancer Research
Recent Publications
Shin KH, Ku JL, Kim WH, Lee SE, Lee C, Kim SW, Park JG. Establishment and characterization of 7 human renal cell carcinoma cell lines. BJU International, 85:130-137, 2000.
Shin KH, Park YJ, Park JG. Mutational analysis of the transforming growth factor beta type II receptor gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients. Clinical Cancer Research, 6:536-540, 2000.
Shin KH, Park JG. Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair genes hMSH2 and hMLH1. European Journal of Cancer, 36:925-931, 2000.
Jang JH, Shin KH, Park YJ, McKeehan WL, Park JG. Inactivation of FGFR3 via use of cryptic splicing sequences and aberrant splicing in colorectal cancer. Cancer Research, 60:4049-4052, 2000.
Park YJ, Shin KH, Park JG. Risk of gastric cancer in hereditary nonpolyposis colorectal cancer in Korea. Clinical Cancer Research, 6:2994-2998, 2000.
Jang JH, Shin KH, Park JG. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 gene associated with human gastric and colorectal cancers. Cancer Research, 61:3541-3543, 2001.
Kim HS, Cho NB, Yoo JH, Shin KH, Park JG, Kim YI, Kim WH. Microsatellite instability in double primary cancers of the colorectum and stomach. Modern Pathology, 14:543-548, 2001.
Shin KH, Park YJ, Park JG. PTEN gene mutations in colorectal cancers displaying microsatellite instability. Cancer Letter, 174:189-194, 2001.
Shin KH, Choe G, Park YJ, Jang JH, Jung HW, Park JG. Establishment and characterization of nine human brain tumor cell lines. In Vitro Cellular and Development Biology, 37:623-628, 2001.
Shin KH, Shin JH, Kim JH, Park JG. Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients: Identification of three novel germline mutations in promoter of the hMSH2 gene. Cancer Research, 62:38-42, 2002.
Lee G, Kim YB, Kim JH, Kim MS, Shin KH, Won YS, Lee JI, Choung PH, Hyun BH, Min BM. Characterization of novel cell lines established from three human oral squamous cell carcinomas. International Journal of Oncology, 20:1151-1159, 2002.
Shin KH, Park KH, Hong HJ, Kim JM, Oh JE, Choung PH, Min BM. Prevalence of microsatellite instability, inactivation of mismatch repair genes, p53 mutation, and human papillomavirus infection in Korean oral cancer patients. International Journal of Oncology, 21:297-302, 2002.
Shin KH, Kim JM, No KS, Park KH, Oh JE, Min BM. Inactivation of PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. International Journal of Oncology, 21:997-1001, 2002.
Shin JH, Ku JL, Shin KH, Shin YK, Kang SB, Park JG. Glutathione S-transferase M1 associated with cancer occurrence in Korean HNPCC families carrying the hMLH1/hMSH2 mutation. Oncology Reports, 10:483-486, 2003.
Kang MK, Kameta A, Shin KH, Baluda MA, Kim HR, Park NH. Senescence-associated genes in normal human oral keratinocytes. Experimental Cell Research, 287:272-281, 2003.
Kameta A, Kang MK, Shin KH, Park NH. Absence of hamTERT gene expression is associated with promoter hypermethylation in immortal hamster buccal pouch epithelial cells. International Journal of Oncology, 22:1351-1356, 2003.
Kang MK, Kameta A, Shin KH, Baluda MA, Park NH. Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells. Journal of Cellular Physiology, 2003 (in press)
Shin KH, Kang MK, Dicterow E, Park NH. Hypermethylation of hTERT gene promoter in normal oral fibroblasts and senescent normal oral keratinocytes. British Journal of Cancer, 2003 (in press)
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