Educational and Professional Background
1979 B.Sc. Simon Fraser University
1981 D.M.D. University of British Columbia
1985 D.M.Sc. Harvard University (Molecular Biology)
1985 Certificate Harvard School of Dental Medicine (Oral Pathology)
Dr. David Wong is the Associate Dean of Research and a Professor in the Division of Oral Biology and Medicine at the UCLA School of Dentistry. He is a graduate of the Faculty of Dentistry at the University of British Columbia in 1981 and then did his graduate training in molecular biology at Harvard University together with a clinical training in oral pathology. Dr. Wong began his career at the Harvard School of Dental Medicine where he held the rank of assistant professor followed by associate professorship and head of the Division of Oral Pathology from 1992 to 2001. In 2002, he joined the UCLA School of Dentistry as Professor and Director of the Dental Research Institute. On January 1, 2003, he was named Chair of the Division of Oral Biology and Medicine, one of the six academic divisions at the UCLA School of Dentistry. On January 1, 2005, he was named Associate Dean of Research for the UCLA School of Dentistry.
Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. An exciting recent effort are two (2), 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center (add URL) and the Human Salivary Proteome project (http://www.hspp.ucla.edu), whereby nano-technology-based microsensors “lab on a chip” will be developed for translational applications for molecular diagnostics for oral cancer and oral pathogens based on oral fluids (saliva). The Human Salivary Proteome project is to decipher the entire catalogue of proteins in human saliva.
Dr. Wong is intimately involved with the research training and career development of dentist-scientists and oral health researchers. He was the program director of the Harvard Institutional Dentist Scientist Program from 1994 to 2001. He has trained over 40 dentist scientists and graduate students. He is the Director of the Oral Biology Graduate Program at UCLA which includes a Short-Term Training Program, a PhD Track, a Master Degree in Clinical Research, the dual degree DDS/PhD program and the advanced clinical training/PhD track. He is also the Program Director of the recently funded “UCLA Fundamental Clinical Research Training Program”, a 5-year comprehensive research-training program funded by the NIDCR. Dr. Wong is the current Chair of the NIDCR Special Grant Review Committee.
Research/Creative Activities
Ongoing Research Support:
p12CDK2-AP1 in Cell Cycle Control and Oral Carcinogenesis
RO1-DE/CA14857-01A1 Wong (PI) 07/01/2003-06/30/2007
NIH/NIDCR/NCI
The aims of this proposal include characterizing the in vivo role of p12CDK2-AP1 as a negative regulator of CDK2 activities and determining how this interaction is involved in the TGF-?? antiproliferative pathway.
Role: PI
UCLA Collaborative Oral Fluid Diagnostic Research Center
UO1-DE15018-01 Wong (PI) 10/01/2002-09/30/2006
NIH/NIDCR
This proposal integrates micro- and nano-microelectronic mechanical system (MEMS/NEMS) technologies to oral fluid as the diagnostic medium to monitor the health and/or disease status of individuals.
Role: PI
UCLA Fundamental Clinical Research Training Grant
T32-DE07296-08 Wong (PI) 07/01/2003-06/30/2008
NIH/NIDCR
The objective of this training program is to provide a rigorous training environment for clinician (DDS/DMD, MD), basic (PhD) and baccalaureate scientists to enable them to pursue academic careers in oral health research. The mission is to foster novel, mentored research highly relevant to oral health by specific curriculum aims in three areas: (1) Bioengineering and Bone Biology, (2) Head and Neck Cancer, and (3) Microbiology and Immunity.
Role: Program Director
Molecular Predictors of Oral Premalignancy Progression
R21 CA94216-01 Wong (PI) 02/01/01 - 01/31/03
NIH/ NCI
The major objective of this proposal is to test the hypothesis that global gene expression monitoring using high-density microarrays offers the potential to identify genes in the malignant progression of oral premalignancies.
Role: PI
Molecular Predictors of Oral Cancer Development
R21/R33 CA 095231-01 Jordan (PI) 04/01/2002 to 03/31/2007
NIH/NCI
This proposal aims to optimize quantitative PCR for the analysis of gene expression in routinely processed oral biopsies and to establish the quantitative requirement for LCM-generated RNA for real-time PCR.
Role: Co-Investigator
Research Infrastructure Improvement for The UCLA SOD
R24 DE015483-01 Wong (PI) 07/01/2003 to 06/30/2004
NIH/NIDCR
This R24 Planning Award application to improve the research infrastructure for oral health research.
Role: PI
Oral Fluid Based Molecular Diagnostics for Head and Neck Cancer
Interdisciplinary Cancer Research Grant Wong (PI) 07/01/02 – 06/30/05
Jonsson Comprehensive Cancer Center
This is a translational research project aiming to integrate bio-NEMS technologies for the ultrasensitive detection of human cancer-associated genes.
Role: PI
Gene Expression Profiling of Human Oral Cancer
Wong (PI) 07/01/02-06/30/04
Affymetrix Inc.
Role: PI
p12DOC-1 and CDK2 in Cell Cycle Regulation and Cancer
F32 DE05763-01 Hu (PI) 04/01/01 - 03/31/04
NIH/ NIDCR
Role: Sponsor/Mentor
Genomic Predictors of Oral Premalignancy Progression
CRFA Fellowship Zhou (PI) 07/15/02 – 07/14/04
Cancer Research Foundation of American
Role: Sponsor/Mentor
Molecular Predictors of Oral Precancer Development
Research Grant Jordan (PI) 07/01/02-06/30/05
Tobacco Related Diseases Research Project
Role: Co-Investigator
Use of Affymetrix 10K SNP Mapping Arrays to Identify Genome-Wide Loss of Heterozygosities (LOHs) in Progressing and Non-Progressing Human Head and Neck Precancers
Genomic Exploratory Grant Wong (PI) 07/01/03-06/30/04
Jonsson Comprehensive Cancer Center
Role: PI
Courses Taught
Lectures in selected courses.
Professional Memberships and Activities:
Academic Appointments:
2002- Professor, UCLA School of Dentistry
2002- Director, Dental Research Institute, UCLA
2002- Member, UCLA Jonsson Comprehensive Cancer Center
2002- Member, UCLA Molecular Biology Institute
2003- Chair, Division of Oral Medicine & Biology, UCLA
Major Committee Assignments (Current):
University of California at Los Angeles
2002- Ad Hoc Committee on DDS/PhD Program
2002- Committee on Accreditation
2003- Research Advisory Committee
2002- Enviromental Health and Safety Committee
2003- Oral Biology Graduate Program Steering Committee
National
2002-2004 Chair, Special Grant Review Committee, NIDCR/ NIH
2002- Review Committee, Loan Repayment Program, NIDCR/ NIH
2003- Board Member, Oral Cancer Foundation
2003- Vice President, Experimental Pathology & Medicine Group, IADR
Professional Society Involvement:
1981- Omicron Kappa Upsilon Dental Society
1982- American Academy of Oral Pathology
1983- American Association for the Advancement of Science
1985- American Association for Dental Research
1986- International Association for Dental Research (IADR)
1986- IADR/Experimental Pathology & Medicine Group
1986- American Association for Cancer Research
1986- American Society for Microbiology
Recent Publications
- Matsuo K, Shintani S, Tsuji T, Nagata E, Lerman M, McBride J, Nakahara Y, Ohyama H, Todd R, Wong DTW. p12DOC-1, a growth suppressor, associates with DNA polymerase ?/primase. FASEB J. 2000; 14: 1318-1324.
- Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Todd R, Lerman M, Wong DTW. p12DOC-1 is a novel CDK2-associated protein. Mol Cell Biol 2000; 20:6300-6307.
- Tsuji T, Usui SU, Aida TA, Tachikawa TT, Sasaki AS, Matsumura TM, Todd R, Wong DTW. Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme. Oncogene 2001; 20: 24-33.
- Suliman Y, Opitz OG, Avadhani A, Burns TF, El-Deiry WS, Wong D, Rustgi AK. p63 expression is associated with p53 loss in oral-esophageal epithelia of p53 deficient mice. Cancer Res 2001; 61: 6467-6473.
- Shintani S, Mihara M, Terakado N, Nakahara Y, Matsumura T, Kohno Y, Ohyama H, McBride J, Kent R, Todd R, Tsuji T, Wong DTW. Reduction of p12DOC-1 expression is a negative prognostic indicator in Japanese patients with surgically resected oral cancer. Clin Cancer Res 2001; 7: 2776-2782.
- Alevizos I, Mahadevappa M, Ohyama H, Zhang X, Kohno Y, Posner M, Gallagher GT, Varvares M, Cohen D, Kim D, Kent R, Donoff RB, Todd R, Warrington JA, Wong DTW. Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene 2001;20: 6196-6204.
- Todd R, Wong DT. Microarrays and Oral Cancer. J. Dent. Res. 2002; 81: 89-97.
- Kim Y, Tsuji T, Elovic A, Shintani S, Mihara M, Salih E, Kohno Y, Chin B-R, Patel V, Wong D, Todd R. Murine doc-1 cDNA cloning, sequencing and expression in normal adult tissues. Int J Oral Biol 2002; 26: 87-92.
- Shintani, S, Mihara, M, Nakahara, Y, Kiyota, A, Ueyama, Y, Matsumura, T, and Wong, DTW. Expression of cell cycle control proteins in normal epithelium, premalignant and malignant lesions of oral cavity. Oral Oncology 2002, 38: 235-243.
- Todd R, Hinds PW, Münger K, Rustgi AK, Opitz OG, Suliman Y, D.T. W. Cell Cycle Dysregulation in Oral Cancer. Critical Review of Oral Biology 2002; 51-56.
- Kohno Y, Kim Y, Donoff RB, Kent R, Wong DT, Tsuji T, Chin BR, Todd R. Apoptosis, Proliferation and p12doc-1 Profiles in Normal, Dysplastic and Malignant Squamous Epithelium of the Syrian Hamster Cheek Pouch Model. Oral Oncol 2002; 38: 274-280.
- Mihara M, Shintani S, Kiyota A, Matsumura T, Wong DT. Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. Int J Oncol 2002; 21: 95-101.
- Alevizos, I., Gallagher, G., Ohyama, H., Wong, D. T. W., and Todd, R. Odontogenic carcinoma: a functional genomic comparison with oral mucosal squamous cell carcinoma. Eur J Cancer-Oral Oncology, 2002, 38: 504-507.
- Kim Y, Flynn T, Donoff RB, Wong DT, Todd R. The gene: the polymerase chain reaction (PCR) and its clinical application. J. Oral & Maxillofacial Surg 2002; 60: 805-815.
- Ohyama H, Mahadevappa M, Luukkaa H, Todd R, Warrington J, Wong DT. Use of LCM-Generated Targets for Hybridization of High-Density Oligonucleotide Arrays. In: Conn PM, ed. Methods in Enzymology. 2002, 356: 323-333.
- Kim Y, Donoff RB, Wong DT, Todd R. The nucleotide: DNA sequencing and its clinical application. J Oral and Maxillofacial Surg 2002; 60: 924-930.
- Macabeo-Ong M, Ginzinger DG, Dekker N, McMillan A, Regezi JA, Wong DT, Jordan RC. Effect of duration of fixation on quantitative reverse transcription polymerase chain reaction analyses. Mod Pathol 2002; 15: 979-87.
- Kiyota A, Shintani S, Mihara M, Nakahara Y, Ueyama Y, Matsumura T, Tachikawa T, Wong DT. Anti-epidermal growth factor receptor monoclonal antibody 225 upregulates p27(KIP1) and p15(INK4B) and induces G1 arrest in oral squamous carcinoma cell lines. Oncology 2002; 63: 92-8.
- Hwang D, Alevizos I, Schmitt WA, Misra J, Ohyama H, Todd R, Mahadevappa M, Warrington JA, Stephanopoulos G, Wong DT. Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling. Oral Oncol 2003; 39: 259-68.
- Macabeo-Ong, M., C. H. Shiboski, et al. (2003). "Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression." Oral Oncol: in press.
- Todd, R., Gutkind, J. S., Shillitoe, E., and Wong, D. T. W. (2002). In: Solid Tumors: Microarray analysis of oral cancers. In Microarrays in Cancer Research, J. Warrington, R. Todd, and D. T. Wong, eds. (Framingham, MA, Eaton).
- Wong, D. T. W., Rustgi, A. K., Todd, R., and Shklar, G. (2003). Animal Models for Head and Neck Cancer Research. In Head and Neck Cancer, J. F. Ensley, J. S. Gutkind, and S. Lippman, eds. (Elsevier Science), pp. 57-63.
Additional Information
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"The UCLA School of Dentistry is a visionary dental school with leadership determined to advance dental education and clinical practices through research. The School of Dentistry is well integrated into the intellectual and scientific fabric at UCLA and is poised to become one of the premier dental school in the country and the world." |
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