• Contact Information
• Educational and Professional Background
• Research/Creative Activities
• Courses Taught
• Professional Memberships and Activities
• Recent Publications

Educational and Professional Background

University of Southern California, Ph.D. in Molecular Biology, 1983

Dr. Chiu is an established molecular biologist. His research interest is in signal transduction involved in transcriptional regulation and cell differentiation. Currently, he is a Professor at UCLA School of Dentistry, Surgical Oncology/School of Medicine, member of Jonnson Comprehensive Cancer Center, and UCLA ACCESS faculty member.

Research/Creative Activities

Functional role of cyclophilin A in neurogenesis
Function of mitogen-activated protein kinase phosphatases (MKPs) in epithelial cell transformation
Mechanisms of the drugs induced gingival overgrowth

Courses taught

OB412b Fundamentals of Pharmacology & Dental Therapeutics
OB201C Advanced Oral biology-Pathobiology

Professional memberships and activities:

American Association for the Advancement of Science
American Society for Microbiology
American Association for Cancer Research

Recent Publications

1. Zhou, H., Lin, A., Gu, Z., Chang, S., Park, N.-H. and Chiu, R. (2000) 12-O-Tetra-decanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA- inducible JNK activity. J. Biol. Chem. 275:22868-22875
2. Zhou, H., Le, D., Huynh, T., Park, N.-H. and Chiu, R. (2000) UV-induced JNK activity does not correlate with UV-induced cell death in human oral keratinocytes. Intl. J. Oral Biol. 25:31-38
3. Kawasaki, H., Schiltz, L., Chiu, R., Itakura, K., Taira, K., Nakatani, Y. and Yokoyama, K. K. (2000) ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature 405:195-200
4. Jin, C., Li, H., Murata, T., Sun, K., Horikoshi, M., Chiu, R. and Yokoyama, K.K. (2002) JDP2, a repressor of AP-1, recruits a hstone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. Mol. Cell. Biol. 22:4815-4826
5. Cui, Y., Mirkia, K., Fu, Y.-H. F., Zhu, L., Yokoyama, Y. and Chiu, R. (2002) Intreraction of the retinoblastoma gene product, RB, with cyclophilin A negatively affects cyclopsporin-inhibited NFAT signaling. J. Cell. Biochem. 86:630-641
6. Chiu, R., Rey, O., Zheng, J.-Q., Twiss, J. L. Song, J., Pang, S. and Yokoyama, K. K. (2003) Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonal carcinoma cells. Cell. Mol. Neurobiol. in press